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This study evaluates the possibility of a blood-based test for analyzing the methylation of circulating
cell-free DNA derived from tumor for the potential diagnosis and management of breast cancer patients.

Using the EpiTYPER method, over 30k CpGs from ten breast cancer genes were rapidly profiled.
Significant promoter hypermethylation of eight tumor suppressor genes was seen.
The results suggest the potential of using cancer-specific methylation changes in plasma and serum for
the development of a blood-based test as a predictive and prognostic biomarker.